Butylated hydroxytoluene

What this is

BHT is regulated primarily as a fat-soluble antioxidant rather than as a general preservative for every food. The U.S. still permits BHT under a GRAS tolerance tied to fat or oil content and under separate direct-additive limits for certain foods, but FDA has begun a post-market review of BHT in food and food-contact materials. Codex, Canada, and the EU treat BHT as an allowed additive with category-specific conditions, not as a substance broadly banned from all food. Toxicology reviews focus on animal endpoints such as reproductive or litter effects, liver enzyme induction, and thyroid-related changes, with acceptable daily intakes set below those effect levels. EFSA reported no genotoxicity concern and treated carcinogenicity as thresholded; NTP did not find BHT carcinogenic in its rat/mouse bioassay. The policy picture is now mixed: Louisiana restricts BHT in covered school foods and requires QR-code disclosure for foods containing it, while FDA's review means the U.S. federal position may change.

Safety Review

The key endpoints PRūF reviews in safety assessments. This is not a prediction of harm.

Toxicology reviews focus on higher-dose animal effects such as hepatic enzyme induction, thyroid-related changes, and rat two-generation litter/pup effects used for ADI selection. NTP did not find BHT carcinogenic in its standard rat/mouse bioassay, but FDA is reviewing dietary exposure, toxicity, and GRAS/prior-sanctioned uses.